GLP-1 Support

Science behind this product

Use these facts to educate your customers and promote your products.

Ginger Extract for Nausea Relief - Clinical Trial

A recent clinical trial confirming ginger extract's anti-nausea properties across patient populations. The standardized ginger extract produced measurable reductions in nausea scores, with effects attributed to gingerols and shogaols acting on serotonin (5-HT3) receptors in the gut — the same pathway targeted by some anti-nausea drugs. Ginger's safety profile was excellent, with no significant adverse events. These findings are highly relevant to GLP-1 medication users who commonly experience nausea.

Source

Piperine as Iron Absorption Enhancer

A detailed review focusing on BioPerine®'s (piperine) mechanism as a thermonutrient that stimulates intestinal epithelial cells, increasing the absorption window for co-administered nutrients. Clinical and animal studies showed that iron serum concentrations were significantly higher when co-administered with BioPerine® versus iron alone. Human trials in iron-deficient individuals also showed improved hemoglobin, ferritin, and reduced fatigue scores. The authors conclude piperine is a safe and effective bioavailability enhancer applicable to multiple micronutrients.Source

Magnesium + Zinc for Blood Sugar Regulation

A very recent (2025) study examining combined magnesium and zinc supplementation's impact on insulin sensitivity and blood glucose regulation in human subjects. Results reinforced that deficiencies in both minerals are independently associated with impaired insulin signaling, and that correcting these deficiencies significantly improves fasting glucose and insulin sensitivity metrics. The study highlights these two minerals as foundational micronutrients for metabolic health.Source

Bromelain Anti-Inflammatory Digestive Support

A 2024 study examining bromelain's dual role as a digestive enzyme and anti-inflammatory agent in the gastrointestinal tract. Bromelain was shown to effectively break down dietary proteins, reducing digestive discomfort and bloating, while simultaneously modulating gut inflammation through cytokine inhibition. The study supported bromelain's inclusion in digestive enzyme blends for improving nutrient digestion and reducing GI symptoms, particularly post-meal bloating. The authors noted bromelain's favorable safety profile at supplemental doses.Source

GLP-1 & Alopecia — First Systematic Review

The first comprehensive systematic review of GLP-1-associated hair loss, published in 2025 after searching four databases and screening 133 studies. Among GLP-1 medications, semaglutide and tirzepatide showed the highest incidence of hair loss — predominantly telogen effluvium (stress-triggered shedding triggered by rapid weight loss and nutritional deficits). The review identifies nutrient depletion — specifically zinc, biotin, and iron — as key contributing mechanisms alongside caloric restriction stress on hair follicles. This is significant because this supplement contains all three of these nutrients, making it a scientifically supported intervention for one of the most commonly reported and distressing GLP-1 side effects.Source

Vitamin B12 Deficiency, Homocysteine & Depression/Toxicity

A prospective observational study documenting how low B12 and folate causes elevated homocysteine — a biomarker directly linked to depression, cognitive impairment, and neurological toxicity. Patients with inadequate B12/folate supplementation showed significantly higher rates of treatment complications and depressive symptoms. This is highly relevant to GLP-1 users because the dramatic food intake reduction caused by these medications rapidly depletes B12 and folate — nutrients that require regular dietary intake to maintain. Depression and mood changes are already being reported as potential GLP-1 side effects, and this study shows nutrient depletion may be a contributing mechanism. The supplement's high-dose methylcobalamin B12 and active L-5-MTHF folate directly counteract this risk.Source

Magnesium-L-Threonate Improves Sleep Quality — RCT

A rigorous 2024 randomized, double-blind, placebo-controlled trial in 80 adults with self-reported sleep problems, testing magnesium supplementation for 21 days. The magnesium group showed significant improvements in sleep quality scores, daytime functioning, and reduced sleep onset time compared to placebo. This matters specifically for GLP-1 users because appetite suppression and caloric restriction create magnesium depletion — and magnesium deficiency is one of the most well-documented causes of disrupted sleep. The 200mg of magnesium in this supplement directly addresses this. Sleep disruption is also a key factor in compounding GLP-1 fatigue side effects.Source